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Anti-CUL7 Rabbit Polyclonal Antibody

Supplier: ProSci

Immunohistochemistry staining of Cullin 7 in brain cortex tissue using Cullin 7 Antibody.

Immunohistochemistry staining of Cullin 7 in brain cortex tissue using Cullin 7 Antibody.

49-418

10078-916EA 727.25 USD

10078-916

Anti-CUL7 Rabbit Polyclonal Antibody

Antibodies

Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 7 is a component of E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin 7 seems to be involved proteosomal degradation of proteins involved in endothelial proliferation and/or differentiation. Cullin 7 is part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Cullin 7 interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone.

Cullin 7 antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 5 ?g/mL.

Delipidation and Defibrination

Serum, 0.01% sodium azide.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: CUL7
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human

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