Anti-ATF3 Rabbit Polyclonal AntibodySupplier: Prosci
10078-864EA 582.9 USD10078-864
Anti-ATF3 Rabbit Polyclonal Antibody
ATF3, or Activating Transcription Factor 3, is a member of mammalian activation TF/CREB protein family of transcription factors. ATF3 binds the cAMP response element (cre) (consensus: 5'-gtgacgt[ac][ag]-3'), a sequence present in many viral and cellular promoters. However, ATF3 represses rather than activates transcription from promoters with ATF sites stabilizing inhibitory co-factors at the promoter. Alternate splicing forms of ATF3, called ATF3 delta Zip, lack the leucine zipper domain and do not bind DNA. ATF3 delta Zip stimulates transcription, presumably by sequestering inhibitory co-factors away from the promoter. Human ATF3 (SwissProt 18847) is a 20575 Da protein composed of 181 amino acids.
- ATF3 antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.
0.02 M Potassium Phosphate, 0.15 M NaCl, pH 7.2 with 0.01% (w/v) Sodium Azide
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.