Anti-TNFSF13 Rabbit Polyclonal AntibodySupplier: Prosci
10078-792EA 582.9 USD10078-792
Anti-TNFSF13 Rabbit Polyclonal Antibody
APRIL (a proliferation-inducing ligand) is a newly identified member of the tumor necrosis factor (TNF) family. Ectopic expression of APRIL is associated with the upregulation of X-linked inhibitor of apoptosis protein (XIAP) and may act as antiapoptotic factor. Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. Northern blot analysis revealed weak expression restricted to a few tissues: transcripts of 2.1 and 2.4 kb in prostate and a transcript of 1.8 kb in peripheral blood leukocytes. All tumor cell lines, however, strongly expressed the TNFSF13 2.1-kb transcript, and expression of extracellular or full-length TNFSF13 led to increased proliferation of various cell lines.
TNFSF13 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 5 ?g/mL.
Protein G Column
PBS, 0.1 mg/mL BSA.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.