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Anti-CXCR4 Mouse Monoclonal Antibody [clone: [12G5]]

Supplier: ProSci

Immunohistochemistry staining of CXCR4 in brain cortex tissue using CXCR4 monoclonal Antibody.

Immunohistochemistry staining of CXCR4 in brain cortex tissue using CXCR4 monoclonal Antibody.

49-232

10074-490EA 785.68 USD

10074-490

Anti-CXCR4 Mouse Monoclonal Antibody [clone: [12G5]]

Antibodies

CXCR4, a Chemokine Receptor involved in organ vascularization, neuronal cell migration, and patterning of the central nervous system during development. It binds stromal cell-derived factor 1 (SDF1, also called PBFS) and mediates migration of resting leukocytes and is unique in homing hematopoietic progenitors to bone marrow. These properties suggest that CXCR4 is involved in tumor cell migration and local tumor invasion. It is also an HIV-1 fusion co-factor that allows HIV-1 invasion in diverse human cell types. Although this receptor was initially called Neuropeptide Y3 Receptor, it does not respond to neuropeptide Y. CXCR4 has two isoforms that are produced by alternative splicing.

CXCR4 antibody can be used in immunohistochemistry starting at 10 ?g/mL.

Affinity Chromatography

PBS, pH 7.2, 0.09% sodium azide.

Aliquot and store at 4ºC. Avoid freezing.

Type: Primary
Antigen: CXCR4
Clonality: Monoclonal
Clone: [12G5]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Baboon, Chimpanzee, Human, Monkey

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