Anti-FANCD2 Mouse Monoclonal Antibody [clone: [103]]

Supplier: ProSci
49-194
10078-658EA 674.53 USD
10078-658
Anti-FANCD2 Mouse Monoclonal Antibody [clone: [103]]
Antibodies
Fanconi Anemia Complementation Group D2 (FANCD2) protein is one of at least six factors shown to be involved in the autosomal-recessive cancer-prone disorder, Fanconi Anemia (FA). FA group D has been shown to be comprised of two separate proteins, FANCD1 and FANCD2. Mutations in BRCA2 can cause FANCD1. FANCD2 has been shown to colocalize with BRCA1 in ionizing radiation-induced foci. FANCD2 is involved in genomic resistance to DNA cross-linking reagents, and the arrest of DNA synthesis following exposure to ionizing radiation. FANCD2 has been shown to directly interact with NBS1. FANCD2 is one of at least four different genes, of which when mutated can cause the Fanconi anemia phenotype characterized by congenital defects, progressive bone marrow failure, and cellular hypersensitivity to mitomcyin C. FANCD2 is phosphorylated by ATM following ionizing radiation and this phosphorylation is required for activation of an S-phase checkpoint. It is also monoubiquitinated in response to DNA damage. It is postulated that FANCD2 may have a role in the cellular response to stalled replication forks or in the repair of replication-associated double-strand breaks.

FANCD2 antibody can be used in immunohistochemistry starting at 5.6 ?g/mL.

Protein G Column

PBS, pH 7.2, Contains no preservative.

Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: FANCD2
Clonality: Monoclonal
Clone: [103]
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human
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