Anti-SIRT1 Rabbit Polyclonal AntibodySupplier: Prosci
10078-626EA 582.9 USD10078-626
Anti-SIRT1 Rabbit Polyclonal Antibody
The SIRT family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. Sirtuins utilize NAD+ as a substrate to catalyze deacetylation of specific acetylated protein and histones. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.
SIRT1 antibody can be used in immunohistochemistry starting at 10 ?g/mL.
Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol.
Store SIRT1 antibody at 4 °C. Do not freeze.