Anti-ABCB1 Rabbit Polyclonal Antibody

Supplier: Prosci

10078-272EA 615.27 USD
Anti-ABCB1 Rabbit Polyclonal Antibody
ATP-Binding Cassette Sub-Family B Member 1 (ABCB1, also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates. Human ABCB1 plays an important role in absorption, distribution, metabolism, excretion and toxicity of pharmacologically relevant drugs. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs. This protein also functions as a transporter across the blood-brain barrier.

ABCB1 antibody can be used in Western Blot, and immunohistochemistry starting at 2.5 ?g/mL.

0.02 M potassium phosphate, 0.15 M NaCl, pH 7.2, 0.01% sodium azide.

Aliquot and store at -20°C. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: ABCB1
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Dog, Human, Monkey, Mouse, Rat
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