Anti-PRMT6 Rabbit Polyclonal Antibody

Supplier: Prosci

48-512
10078-174EA 582.9 USD
10078-174
Anti-PRMT6 Rabbit Polyclonal Antibody
Antibodies
Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activit. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus.

PRMT6 antibody can be used in Western Blot, immunohistochemistry starting at 10 ?g/mL, and flow cytometry.

Protein G Column

PBS, 0.02% sodium azide, 0.1 mg/mL BSA.

Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: PRMT6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Monkey
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