Anti-PTPRC Rabbit Polyclonal Antibody

Supplier: Prosci

10078-088EA 582.9 USD
Anti-PTPRC Rabbit Polyclonal Antibody
CD45 is a family of high-molecular weight glycoproteins uniquely expressed on the surface of all leukocytes and their hematopoietic progenitors. The CD45 family consists of multiple members that are all products of a single gene. Structurally, CD45 is composed of one fibronectin extracellular domain, one transmembrane domain, and two cytoplasmic tyrosine phosphatase domains. It is essential for B- and T-cell activation. For both cell-types, CD45 has been shown to interact with kinases including Lyn, src family kinase Lck, and Janus-family kinases. In T cells, CD45 is required for the initiation of receptor signaling by dephosphorylating a negative regulatory tyrosine in the C-terminal tail of Lck. CD45 may also negatively regulate Lck by dephosphorylating the tyrosine in the activation loop, thereby attenuating Lck activity.

PTPRC antibody can be used in immunohistochemistry starting at 0.5 - 1 ?g/mL.

PBS, 0.1% sodium azide.

Aliquot and store at -80°C. Avoid multiple freeze-thaw cycles.

Type: Primary
Antigen: PTPRC
Clonality: Polyclonal
Conjugation: Unconjugated
Host: Rabbit
Reactivity: Gorilla, Human
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