Cavin 1-PTRF has been shown to be an essential component of caveolae. Cavin 1-PTRF appear to be recruited to membrane domains containing PS, cholesterol and oligomerized caveolins. Binding of Cavin 1-PTRF to these domains stabilizes the membrane curvature to produce the classic flask shape of caveolae. Disassembly of Cavin 1- PTRF releases caveolar components, including caveolins into the plasma membrane. Succinctly it appears that Cavin 1-PTRF regulates caveola structure and function.
ELISA, Western (immuno) blotting, Immunostaining (in testing)
Affinity Purified
Type: Primary
Antigen: PTRF
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human