Human Peripheral Blood Natural Killer (NK) Cells, Charles River Laboratories Cell Solutions

Supplier: Charles River Laboratories Cell Solutions
PB56C-1 PB56NC-2 PB56C-2 PB56NC-1
101190-026EA 1730.77 USD
101190-026 101190-024 101190-084 101190-086
Human Peripheral Blood Natural Killer (NK) Cells, Charles River Laboratories Cell Solutions
Blood
Human peripheral blood CD56 NK Cells are isolated from peripheral blood mononuclear cells (PBMCs) using positive or negative immunomagnetic cell separation procedures (upon your request)

PBMCs are collected in HemaCare's FDA-registered collection centers following cGMP and cGTP collection guidelines from healthy human volunteer donors under IRB approved informed consent by leukapheresis using the COBE® Spectra Apheresis System MNC collection protocol. This mononuclear cell-rich leukapheresis product (LeukoPak) is extracted using continuous flow centrifugal technology directly into the collection bag. Mononuclear cells are purified using density gradient centrifugation techniques. Serological and Infectious disease testing are performed with each donation. Customers should handle product as if potentially infectious following biosafety level 2 procedures.

CD56 NK cells activity has recently been a focus of cancer research due to the cell type’s natural ability to seek out and destroy abnormal cells without any kind of MHC signal. Studies have shown that NK cells referred to as lyphikine-activated killers (LAK), can be induced by higher than normal IL-2 levels to increase their cytotoxic activity towards cell lines, like many cancer cells, initially resistant to un-stimulated NK cells.
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