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Anti-ORAI3 Rabbit Polyclonal Antibody

Supplier: ProSci

Anti-ORAI3 Rabbit Polyclonal Antibody

Anti-ORAI3 Rabbit Polyclonal Antibody

Anti-ORAI3 Rabbit Polyclonal Antibody

Anti-ORAI3 Rabbit Polyclonal Antibody

Anti-ORAI3 Rabbit Polyclonal Antibody

Anti-ORAI3 Rabbit Polyclonal Antibody

4215

89416-278EA 531.09 USD

89416-278

Anti-ORAI3 Rabbit Polyclonal Antibody

Antibodies

ORAI3 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2.

Type: Primary
Antigen: ORAI3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse

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