Rat Liver S9 Homogenate, MP Biomedicals

Supplier: MP Biomedicals
0850412
IC50412EA 238.36 USD
IC50412
Rat Liver S9 Homogenate, MP Biomedicals
Cells
Rat Liver S9 Homogenate is a Supernatant fraction obtained from an organ (usually liver) homogenate by centrifuging at 9000 g for 20 minutes in a suitable medium; this fraction contains cytosol and microsomes

  • Inducing Agent: Aroclor 1254

Rat Liver S9 Homogenate is used in Ames Mutagen Assay, to assess the mutagenic potential of chemical compounds. It is also used in assays that measure the metabolism of drugs and other xenobiotics. Many xenobiotics, neurotransmitters, steroids, and other hormones are metabolized by sulfate conjugation, a reaction catalyzed by the class of sulfotransferase enzymes. The common sulfate group donor is adenosine 3’-phosphate 5’-phosphosulfate.

The microsomes component of the S9 fraction contain cytochrome P450 isoforms (phase I metabolism) and other enzyme activities. The cytosolic portion contains the major part of the activities of transferases (phase II metabolism).
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