SMI-4a ≥95% (by NMR)

Supplier: ADIPOGEN CORP MS

Synonyms: (5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedionePim Inhibitor 4a5-(3-(Trifluoromethyl)benzylidene)thiazolidine-2,4-dioneTCS-PIM-1-4a(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione

AG-CR1-3503-M005
102516-222EA 124.62 USD
102516-222
SMI-4a ≥95% (by NMR)
SMI-4a

Selective inhibitor of Pim-1 and Pim-2 protein kinases. Inducer of G1 phase cell cycle arrest. Inducer of p27Kip1. Inducer of apoptosis through the mitochondrial pathway. Inhibitor of the mammalian target of rapamycin C1 (mTORC1) pathway. Downregulates c-myc. Inhibitor of PRAS40 phosphorylation and mTOR activity. Potential anti-cancer compound. Blocks prostate cancer growth.

Formula: C₁₁H₆F₃NO₂S
MW: 273.23 g/mol
Storage Temperature: Freezer
MDL Number: MFCD01152003
CAS Number: 327033-36-3

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Specification Test Results

Purity 95% (NMR)
Appearance/Color White to off-white solid.
Solubility Soluble in DMSO (at least 5 mg/ml).

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