Z-Leu-Leu-Leu-vinyl sulfone, Enzo Life Sciences

Supplier: Enzo Life Sciences
ZW9170-0500
89165-660EA 399.46 USD
89165-660
Z-Leu-Leu-Leu-vinyl sulfone, Enzo Life Sciences
Proteins and Peptides
Inhibits the trypsin-like, chymotrypsin-like and caspase-like (PGPH) activity in isolated proteasomes and living cells by covalent modification of the amino-terminal threonine of the catalytically active beta subunits. The vinyl sulfone acts as a Michael acceptor for soft nucleophiles such as thiols, leading to the formation of a covalent bond, while being resistant to attack by free thiols, which can cause inactivation of other classes of protease inhibitors.
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