TAPI-1 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

BML-PI134-0001
89161-652EA 455.9 USD
89161-652
TAPI-1 ≥98% (by HPLC)
TAPI-1

Inhibitor of TNF-alpha processing


Inhibitor of TNF-alpha processing (IC50 is approximately 100 nM using in vitro TNF peptide cleavage assay), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF-alpha (IC50=50-100 µM)1, APP (1-8 µM), ACE (10 µM), IL6R (5-10 µM), TNFRI (5-10 µM), TNFRII (25-50 µM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.

CAS Number: 171235-71-5

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