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Epoxomicin ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Key inhibitor for use in proteasome research.

Cell permeable, potent and selective proteasome inhibitor originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity. More potent inhibitor of the chymotrypsin-like activity of the proteasome than lactacystin (Prod. No. BML-PI104). Blocks also trypsin-like and PGPH activities of the proteasome. Regulates antigen presentation at non-toxic doses. Effectively inhibits NF-kappaB activation in vitro and potently blocks inflammation in vivo in the mouse ear edema assay.The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by Epoxomicin activates autophagy.

Formula: C₂₈H₅₀N₄O₇
MW: 554.7 g/mol
MDL Number: MFCD03791061
CAS Number: 134381-21-8



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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µg BML-PI127-0100 89161-634 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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