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Ingenol-3,20-dibenzoate ≥97%

Supplier: Enzo Life Sciences
Warning

PE186-0001
Ingenol is a diterpenoid related to phorbol. Activates protein kinase C (PKC) and competes with [3H]phorbol dibutyrate for binding to PKCα (Ki for binding=240 nM). Induces apoptosis. Anticancer agent. Shows potent antileukemic activity in the P388 mouse assay.

Displays unusually high mouse ear inflammatory activity, even though the 20-hydroxy group is blocked with a benzoate ester. It appears likely that this high potency is due to metabolic cleavage of the 20-benzoate group, which releases the more potent ingenol 3-benzoate.

Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).

Synonym: IDB


Formula: C₃₄H₃₆O₇
MW: 556,7 g/mol
Storage Temperature: Freezer
CAS Number: 59086-90-7
Specification Test Results
Purity ≥97%


 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg BML-PE186-0001 89161-416 Each Retrieving Restricted

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