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Thapsigargin ≥99% (by HPLC)

Supplier: Enzo Life Sciences

BML-PE180-0005 BML-PE180-0001

89161-412EA 420.23 USD

89161-412 89161-410

Thapsigargin ≥99% (by HPLC)

Thapsigargin

ATPase inhibitor

Cell permeable tumor promoter. Induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the (sarco)endoplasmatic reticulum Ca2+-ATPase (SERCA) (IC50=30nM). Inhibition of SERCA reveals a significant change in intracellular Ca2+ homeostasis and pH regulation in tumor cells. May be used to distinguish between discrete intracellular Ca2+ pools. Thapsigargin-induced tumor promotion and down regulation of the EGF receptor is independent of PKC activation. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis. Stimulates nitric oxide (NO) production, contributing to hepatocyte apoptosis.

Formula: C₃₄H₅₀O₁₂

MDL Number: MFCD00083511
CAS Number: 67526-95-8

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