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IKK-NBD peptide, Enzo Life Sciences

Supplier: Enzo Life Sciences
NF-kappaB inhibitor

The peptide consists of two domains - an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKbeta which is the NEMO binding domain (NBD). It is a selective inhibitor of NFkappaB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IkappaB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFalpha and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University



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Size Supplier No. VWR Catalog Number Unit Price Quantity
0.5 mg BML-P607-0500 89161-290 Each Retrieving Restricted

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Protein/Peptide Name IKK-NBD peptide
Purity ≥95% (HPLC)
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