Ac-AAVALLPAVLLALLAPYVAD-CHO, Enzo Life Sciences

BML-P404-0005
89161-238EA 158.77 USD
89161-238
Ac-AAVALLPAVLLALLAPYVAD-CHO, Enzo Life Sciences
Caspase inhibitor.

The YVAD-CHO portion of this peptide is a highly-specific, potent (Ki=1 nM) and reversible inhibitor of caspase-1 (interleukin-1ß converting enzyme, ICE), whose sequence is based on the pre-interleukin-1ß Asp-116 cleavage site for caspase-1. The sequence linked N-terminal to YVAD-CHO (residues 1-16) has been shown to enhance cell permeability, as described for P-414. The efficacy of the resulting chimeric peptide, for caspase-1 inhibition, is unknown.
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