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R18 peptide, Enzo Life Sciences

Supplier: Enzo Life Sciences
14-3-3 inhibitor

The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments. A biotinylated form is available (BML-P225), allowing detection using streptavidin.



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Size Supplier No. VWR Catalog Number Unit Price Quantity
1 mg BML-P214-0001 89161-092 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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Protein/Peptide Name R18 peptide
Purity 95%
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