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Lorcainide hydrochloride ≥98% (by TLC)

Supplier: Enzo Life Sciences

BML-NA143-0010 NA143-0050
Na+ channel blocker

Possesses both local anesthetic and antiarrhythmic properties (class 1C agent). Elevates the ventricular fibrillation threshold and protects against ouabain-induced arrhythmias in animal models. Its mechamism of action is primarly inhibition of sodium channels in a voltage- and frequency-dependent fashion. Also inhibits the microsomal Na+,K+-ATPase in a concentration-dependent manner (IC50=33.5µM) . Reduces neuronal death in cellular models of hypoxic injury when combined with a glutamate receptor antagonist and blocks aconitine-induced mortality in a rat model (ED50=30mg/kg).

Formula: C₂₂H₂₈Cl₂N₂O
MW: 407.379 g/mol
CAS Number: 58934-46-6



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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 mg BML-NA143-0010 89160-704 Each Retrieving Restricted
50 mg BML-NA143-0050 89160-706 Each Retrieving Restricted
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