Gambogic amide ≥98% (by TLC)

Supplier: Enzo Life Sciences


N159-0005 N159-0001
89160-606EA 392.05 USD InStock
89160-606 89160-604
Gambogic amide ≥98% (by TLC)
Gambogic amide

TrkA ligand

A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.

Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).

Formula: C₃₈H₄₅NO₇
MW: 627,8 g/mol
Melting Pt: 74…76 °C
Storage Temperature: Ambient
CAS Number: 286935-60-2

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Specification Test Results

Purity ≥98% (TLC)
Appearance Yellow-orange solid
Melting Point 74 - 76°C

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