Gambogic amide ≥98% (by TLC)Supplier: Enzo Life Sciences
A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.
Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).
MW: 627,8 g/mol
Melting Pt: 74…76 °C
Storage Temperature: Ambient
Specification Test Results
|Melting Point||74 - 76°C|