12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE) ≥98%

Supplier: Enzo Life Sciences

Synonyms: 12(S)-HPETE

BML-HP012-0050
89160-096EA 416.14 USD
89160-096
12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE) ≥98%
12(S)-Hydroperoxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HPETE)

Primary metabolite of arachidonic acid via the 12-lipoxygenase pathway. Inhibits thromboxane synthase. Inhibits platelet aggregation via activation of guanylate cyclase (100% at 5µM). Stimulates leukotriene biosynthesis. Potent and selective inhibitor of Ca2+-calmodulin-dependent protein kinase II (IC50=0.7µM). Endogenous TRPV1 agonist (Ki=0.35µM).


  • Thromboxane synthase inhibitor


Liquid.


Soluble in DMSO or dimethyl formamide; slightly soluble in PBS, pH 7.2 (0.8mg/ml) or 0.1M Na2CO3 (2mg/ml).

Formula: C₂₀H₃₂O₄
MW: 336.5 g/mol
Storage Temperature: Ultra-Low Temperature Freezer (–80°C)
CAS Number: 71774-10-2
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