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Anti-HMOX1 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
HC3001-0025 HC3001-0100
The rate limiting enzyme in heme catabolism, heme oxygenase, was first described in 1968 and was thought to be a species of cytochrome P450. However, subsequent work showed the enzyme to be a protein distinct from the P450 family and capable of catalysing the degradation of heme to biliverdin and iron, with the concomitant release of carbon monoxide. This enzyme activity is highly conserved throughout the Animal Kingdom and has been identified in algae and plants as well as in all higher species. Heme oxygenase-1 (HO-1) was first purified to homogeneity from rat liver and pig spleen and shown to have a molecular weight of 32kDa. Increased expression of HO-1 can be induced by a large number of structurally unrelated pharmacological and other agents, including cytokines and oxidants, as well as by heat shock and other forms of cellular stress. Baseline levels of HO-1 expression are high in certain tissues, including spleen and liver, but enriched enzyme preparations are recommended for experimental analysis. Recent data have demonstrated a cytoprotective role for HO-1, preventing cell death by modulating intracellular iron levels.

For Immunohistochemistry, Western Blot

Recognizes human heme oxygenase 1.

Type: Primary
Antigen: HMOX1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL HC3001-0100 89160-054 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

25 µL HC3001-0025 89160-052 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol HMOX1
Antigen Name Heme Oxygenase 1
Reactivity Human
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms Hsp32, HMOX1, heme orygenase 1, HO-1, heat shock protein 32 heat shock protein 32, Hsp32, heme orygenase 1, HO-1, HMOX1
Form Liquid. Antiserum containing 10mM sodium azide.
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