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Garcinol ≥95% (by TLC)

Supplier: Enzo Life Sciences

GR343-0050 BML-GR343-0010
HAT inhibitor

Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50=7µM) and PCAF (IC50=5µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. It induces apoptosis in HeLa cells (100µM) where it down regulates global gene expression. Acetylation of histone H4 by p300 was more sensitive to inhibition by garcinol compared with that of H3. Histone H4 acetylation was completely inhibited at 1 µM while acetylation of H3 was not abolished at 20 µM.


CAS Number: 78824-30-3


 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
10 mg BML-GR343-0010 89158-978 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

50 mg BML-GR343-0050 89158-980 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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