Cyclopamine ≥98% (by TLC)

Supplier: Enzo Life Sciences

BML-GR334-0005 BML-GR334-0001
89158-958EA 611.56 USD
89158-958 89158-956
Cyclopamine ≥98% (by TLC)
Cyclopamine

Blocks Hedgehog signaling


Cyclopamine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling. It specifically inhibits the hedgehog (Hh) pathway by interaction with the Hh signaling protein smoothened. Cyclopamine blocks the oncogenic effects of mutations of Ptch in fibroblasts and inhibits the growth of cells lacking Ptch function. It arrested cell cycle at G0/G1 and induced apoptosis in several small-cell lung cancer cell lines at 5 µM. Cyclopamine also induces expression of the transcription factor pdx-1, which stimulates insulin secretion in differentiation protocols for mouse embryonic stem cells

Formula: C₂₇H₄₁NO₂
MDL Number: MFCD09878269
CAS Number: 4449-51-8
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