Trichostatin A ≥99% (by HPLC)

Supplier: Enzo Life Sciences

Synonyms: TSA[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

BML-GR309-0001 BML-GR309-0005
89158-876EA 672.84 USD
89158-876 89158-874
Trichostatin A ≥99% (by HPLC)
Trichostatin A

HDAC inhibitor


Trichostatin A (TSA) is a potent and reversible inhibitor of histone deacetylases. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression (IC50=73 nM) and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Induces cell growth arrest at both G1 and G2/M phases. may induce apoptosis in some cases.


Isolated from Streptomyces hygroscopicus

Formula: C₁₇H₂₂N₂O₃
MW: 302.37 g/mol
MDL Number: MFCD03848392
CAS Number: 58880-19-6
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