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CITCO

Supplier: Enzo Life Sciences
Warning
Synonyms: 6-(4-Chlorophenyl)imidazo[2,1-b] [1,3]thiazole-5-carbaldehyde O-3,4-dichlorobenzyl) oxime

BML-GR233-0025 BML-GR233-0005
Constitutive androstane receptor ligand.

CITCO is a novel potent and selective agonist for the human orphan nuclear receptor CAR (constitutive androstane receptor). CITCO displayed an EC50 of 49 nM in a CAR FRET assay and showed 50-fold selectivity for CAR over PXR. CITCO displayed no activity against a panel of 15 other nuclear receptors at a concentration of 10 µM. In hepatocytes CITCO induced CAR nuclear translocation and induced the CAR target gene CYP2B6.

Soluble in DMF (25 mg/mL) or DMSO (10 mg/mL).


Formula: C₁₉H₁₂Cl₃N₃OS
MW: 436,7 g/mol
Storage Temperature: Freezer
CAS Number: 338404-52-7


 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
5 mg BML-GR233-0005 89158-814 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

25 mg BML-GR233-0025 89158-816 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

restricted In order to process your orders without delay, we request that you provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

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* Please note if your account is within the State of California two of these pieces of identification will be required.
VWR will not lift restrictions for residential shipping addresses.

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