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Ar231453 ≥98% (by HPLC), yellow solid

Supplier: Enzo Life Sciences

BML-GP100-0005 BML-GP100-0025
GPR119 activator.

Synthetic agonist of the orphan GPR119. Although endogenous lipid amides such as oleoyl ethanolamide have been reported to be agonists at GPR119, AR231453 is the first reported high potency agonist (EC50=0.68nM). The compound displayed in vivo activity in rodents and was active in an oral glucose tolerance test in mice following oral administration. AR231453 stimulated the release of GLP-1 via GPR119 receptors in mouse models. It was shown to be a highly selective ligand with no off-target activity across a 76 receptor and enzyme profiling panel (CEREP) and no activity against 140 known and orphan GPCRs in melanophore dispersion assays.

Soluble in DMSO (>25 mg/mL).

Formula: C₂₁H₂₄FN₇O₅S
MW: 505.525 g/mol
Storage Temperature: Freezer
CAS Number: 733750-99-7
Specification Test Results
Purity ≥98% (HPLC)
Identity Determined by NMR



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Size Supplier No. VWR Catalog Number Unit Price Quantity
5 mg BML-GP100-0005 89158-710 Each Retrieving Restricted
25 mg BML-GP100-0025 89158-712 Each Retrieving Restricted
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