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Anti-GAD1 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
GC3008-0025 GC3008-0100
Glutamic acid decarboxylase (GAD; E.C. 4.1.1.15) is the enzyme responsible for the conversion of glutamic acid to γ-aminobutyric acid (GABA) - the major inhibitory transmitter in higher brain regions. Two molecular forms of GAD (GAD65 and GAD67) are known from rat, cat, pig and man, and both forms are expressed in the CNS and in pancreatic islet endocrine cells. A recent Western blotting study has identified that the isoforms are regionally distributed in the brains of rats and mice. In rat pancreas, GAD65 and GAD67 appear to be differentially localised, GAD65 primarily in insulin-containing (β) cells and GAD67 in glucagon-containing (A) cells. Evidence from knock-out mice suggests that GABA generated by pancreatic GAD isoforms is not critically involved in normal islet cell development and morphology. However, β-cell-specific GAD expression has been shown to be required for the development of autoimmune diabetes in non-obese diabetic (NOD) mice.

For ELISA, Flow Cytometry, Immunohistochemistry, Western Blot

Recognizes human, mouse, rat and cat GAD. Detects two isoforms of ~65kDa and ~67 kDa by Western Blot.

Type: Primary
Antigen: GLUTAMATE DECARBOXYLASE
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL GC3008-0100 89158-704 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

25 µL GC3008-0025 89158-702 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol GAD1
Antigen Name Glutamate Decarboxylase 1 (brain 67kDa)
Reactivity Human
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
Antigen Synonyms glutamate decarboxylase 1, GAD1, 67kDa), FLJ45882, CPSQ1, GAD25, GAD, glutamate decarboxylase 1 (brain, OTTHUMP00000041055, GAD67, 67kD), SCP GAD, GAD25, glutamate decarboxylase 1, OTTHUMP00000041055, 67kD), FLJ45882, CPSQ1, GAD67, GAD1, glutamate decarboxylase 1 (brain, SCP, 67kDa)
Purification Protein A-affinity chromatography
Form Liquid. In PBS containing 0.09% sodium azide.
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