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Anti-GCG Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
GA1181-0025
The existence of a pancreas-derived hyperglycaemic factor has been known for over 70 years, but it was not until 1983 that the primary structure of the human glucagon precursor molecule was described. The human prepro-glucagon gene encodes a 180 amino acid, 21kDa protein which includes one copy each of the biologically active molecules glucagon and glucagon-like peptides 1 and 2 (GLP-1 and GLP-2).

Pro-glucagon is cleaved in the pancreatic A-cells to release glucagon and the other pro-glucagon-derived peptides, but in enteroglucagon (EG)-containing L-cells of mammalian gut the enzymatic conversion of ‘glicentin’ to ‘pancreatic’ glucagon does not occur. Recent work has shown that prohormone convertase-1 (PC1) is capable of processing pro-glucagon to produce the intestinal peptides, glicentin, oxyntomodulin and GLPs, whereas PC2 processes pro-glucagon to glicentin but does not produce glucagon either alone or in combination with other enzymes or with other known molecular chaperones.

For Immunohistochemistry

Recognizes mammalian glucagon.

Type: Primary
Antigen: GLUCAGON
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Mammals




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Size Supplier No. VWR Catalog Number Unit Price Quantity
25 µL GA1181-0025 89158-698 Each Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol GCG
Antigen Name Glucagon
Reactivity Mammals
Clonality Polyclonal
Antibody Type Primary
Host Rabbit
ImmunoChemistry Yes
Antigen Synonyms GRPP, Glicentin-related Polypeptide, GCG, Glucagon-like Peptide 1, Glucagon-like Peptide 2, GLP1, GLP2
Form Liquid. Neat serum.
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