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Brefeldin A ≥98% (by TLC)

Supplier: Enzo Life Sciences
Synonyms: Brefeldin A, natural

G405-0100 G405-0025 BML-G405-0005
GEF inhibitor

Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.

Isolated from Eupenicillium brefeldianum.


Formula: C₁₆H₂₄O₄
MW: 280.4 g/mol
MDL Number: MFCD00083258
CAS Number: 20350-15-6


 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 mg BML-G405-0100 89158-626 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

25 mg BML-G405-0025 89158-624 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

5 mg BML-G405-0005 89158-622 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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