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Anti-SPTAN1 Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences
FG6090-0100 FG6090-0500
Fodrin, also referred to as non-erythroid (αII-; brain) spectrin, is a tetrameric (αγ)2 actin-binding, fibrous protein, widely distributed in vertebrates, which forms part of the sub-membranous cytoskeleton within many cell types including neurons, and is particularly abundant with axons. The α-subunits of fodrins and spectrin are highly conserved phylogenetically, with the exception of human α-fodrin, which shares only 55-59% homology with erythroid-specific α-spectrins. The β-subunits of spectrin (and γ-subunits of fodrins) are species specific. The interleukin-1 converting enzyme (ICE) family of proteases has been implicated as important effectors of the apoptotic pathway, perhaps acting hierarchically in a protease cascade. Neuronal fodrin is known to be cleaved by calpain following ischaemic insult and it has been proposed that calpain and an unidentified protease play a role in the onset of neuronal death following transient forebrain ischaemia. Recently, an ICE-like protease has been implicated in the early cleavage of fodrin, producing a 150kDa fragment, proximal to CPP32 in Fas-induced and C2-ceramide mediated apoptosis. A cleavage product of α-fodrin has been proposed as a candidate autoantigen in primary Sjögren’s syndrome and α-fodrin has been shown to be the source of a so-called ‘inhibitory protein factor’ family, members of which have been shown to inhibit both GABA and ATP-dependent glutamate uptake into purified synaptic vesicles.

For Immunohistochemistry, Western Blot

Recognizes mammalian and chicken alpha-fodrin

Type: Primary
Antigen: SPTAN1
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Mammals




 

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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL FG6090-0100 89158-462 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

500 µL FG6090-0500 89158-464 Each Retrieving Restricted

Temperature sensitive This Item is temperature-controlled and may have specific temperature and storage requirements for shipping/delivery.

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SPECIFICATIONS

Antigen Symbol SPTAN1
Antigen Name Spectrin, Alpha, Non-Erythrocytic 1
Reactivity Mammals
Clonality Monoclonal
Antibody Type Primary
Host Mouse
Isotype IgG1
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms brain, alpha-II spectrin, SPTA2, fodrin alpha chain, spectrin, EIEE5, NEAS, non-erythroid alpha chain, spectrin alpha chain brain, EIEE5, fodrin alpha chain, SPTA2, spectrin alpha chain, NEAS, spectrin, alpha-II spectrin, non-erythroid alpha chain
Concentration 100µg/ml
Purification Partially purified
Form Liquid. In PBS containing 10mM sodium azide.
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