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Anti-FN1 Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences
FG6010-0100
Fibronectins are high molecular weight, disulphide-linked, dimeric cell adhesion glycoproteins found in basement membranes and in the interstitial connective tissue matrix. A single fibronectin gene is subject to alternative splicing in a cell-type-, development- and age-regulated manner which gives rise to multiple molecular forms. In addition to their prominent role in adhesion, fibronectins have been reported to mediate various aspects of cellular interaction, including migration during development and wound-healing, haemostasis, and the regulation of cell growth and differentiation. Cellular fibronectins (cFn) are found in low amounts in normal human plasma and tissues, but they are abundant in the plasma of carcinoma patients and in the stroma of various carcinomas. In contrast, a soluble form of fibronectin produced by hepatocytes is readily detectable in plasma and becomes deposited in pericellular matrices and within tissues. This form of fibronectin, referred to as ‘plasma fibronectin’ (pFn), differs from cFn by the absence of an amino acid sequence, known as extra domain A1.

For Immunocytochemistry, Western Blot

Recognizes the extra domain A (ED) of cellular fibronectin (cFn). Detects a band of ~ 250kDa by Western blot. Recognizes cFN in malignant tumors, does not cross-react with benign tumors or normal tissues.

Type: Primary
Antigen: FIBRONECTIN
Clonality: Monoclonal
Clone:
Conjugation:
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human




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Size Supplier No. VWR Catalog Number Unit Price Quantity
100 µL FG6010-0100 89158-458 Each Retrieving Restricted

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SPECIFICATIONS

Antigen Symbol FN1
Antigen Name Fibronectin
Reactivity Human
Clonality Monoclonal
Antibody Type Primary
Host Mouse
Isotype IgG1
Western Blot Yes
ImmunoChemistry Yes
Antigen Synonyms ED-B, GFND2, MSF, GFND, FN, Cold insoluble globulin, LETS, CIG, FINC, FNZ, fibronectin 1
Purification Protein A affinity chromatography
Form Liquid. In PBS containing 0.1% sodium azide and 1mg/mL BSA.
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