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Ko143 ≥96% (by HPLC)

Supplier: Enzo Life Sciences

Ko143 ≥96% (by HPLC)

Ko143 ≥96% (by HPLC)

Synonyms: (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino-[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester

BML-EI396-0025 BML-EI396-0005

89158-272EA 826.81 USD

89158-272 89158-270

Ko143 ≥96% (by HPLC)

Ko143

Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.

BCRP inhibitor

White solid.

Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).

Formula: C₂₆H₃₅N₃O₅
MW: 469.6 g/mol
Storage Temperature: Freezer

CAS Number: 461054-93-3

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