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VAS-2870 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

VAS-2870 ≥98% (by HPLC)

VAS-2870 ≥98% (by HPLC)

Synonyms: 3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine , 2-((3-Benzyl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)thio)benzo[d]oxazole

BML-EI395-0010 BML-EI395-0050

89158-268EA 595.17 USD

89158-268 89158-266

VAS-2870 ≥98% (by HPLC)

VAS-2870

Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM).

NADPH oxidase inhibitor

White to off-white solid.

Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml).

Formula: C₁₈H₁₂N₆OS
MW: 360.4 g/mol
Storage Temperature: Ambient

MDL Number: MFCD03407188
CAS Number: 722456-31-7

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