Apigenin ≥97% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone4',5,7-Trihydroxyflavone5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one4',6'-Dihydroxy-2-(4-hydroxyphenyl)benzo(e)oxacyclohex-2-en-4-on5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one5,7-Dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

BML-EI345-0020 BML-EI345-0100
89158-138EA 458.63 USD
89158-138 89158-136
Apigenin ≥97% (by TLC)

Antioxidant and chemopreventive

Apigenin is an antioxidant flavonoid. Has chemopreventive and antitumor  properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. Is a MAP-Kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression. Induces gastric relaxation in mouse stomach, mainly by suppressing Ca2+ influx through voltage-dependent calcium channels. Apigenin is a selective inhibitor of CK2. In WEHI 231 cells inhibition of CK2 by apigenin decreased the rate of IκBα turnover and nuclear levels of NF-κB (20 µM). It blocks proliferation of Wnt-1 transfected cells and abrogates phosphorylation of β-catenin. In a rat model of glomerulonephritis, inhibition of CK2 by apigenin ameliorates renal dysfunction.

Formula: C₁₅H₁₀O₅
MW: 270.24 g/mol
MDL Number: MFCD00006831
CAS Number: 520-36-5

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