17-AAG ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 17-(Allylamino)-17-demethoxygeldanamycin(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(Allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

BML-EI308-0001
89158-030EA 310.42 USD
89158-030
17-AAG ≥98% (by TLC)
17-AAG

HSP90 inhibitor


17-AAG is a less toxic and more stable analog of geldanamycin. It is an HSP90 inhibitor that displays a 100-fold higher affinity for HSP90 derived from tumor cells compared to HSP90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol, cisplatin, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α. Inhibitor of telomerase activity. Inducer of apoptosis with antitumor activity. Inducer of macroautophagy.


Semisynthetic derivative from geldanamycin.

Formula: C₃₁H₄₃N₃O₈
MW: 585.7 g/mol
MDL Number: MFCD04973892
CAS Number: 75747-14-7
https://us.vwr.com/stibo/web/std.lang.all/37/56/45403756.jpg

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR