PP1 ≥98% (by TLC)

Supplier: Enzo Life Sciences

Synonyms: 1-(tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

BML-EI275-0005 BML-EI275-0001
89157-942EA 118.08 USD
89157-942 89157-944
PP1 ≥98% (by TLC)
PP1

Src kinase inhibitor


A highly potent and selective inhibitor of Src family tyrosine kinases, IC50=5 nM for p56lck; p59fynT=6 nM; p60src=170 nM. Inhibition of Src family kinases by PP1 has been shown to: prevent a-thrombin-stimulated Akt phosphorylation, delay PAF-mediated STAT3 phosphorylation, block Zn2+-induced Ras activation, block adhesion-dependent tyrosine phosphorylation of p105HEF1 5, and inhibit HLA-DR-induced tyrosine phosphorylation without affecting the activation of ERK1/2.

Formula: C₁₆H₁₉N₅
MW: 281.4 g/mol
MDL Number: MFCD01076570
CAS Number: 172889-26-8
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