Damnacanthal ≥95% (by HPLC)
Supplier: Enzo Life Sciences
Synonyms:
3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
Damnacanthal is a potent and selective inhibitor of p56lck tyrosine kinase. It inhibits p56lck autophosphorylation (IC50=17 nM) as well as phosphorylation of exogenous substrates (IC50=620 nM) in cell-free assays. Damnacanthal shows a 10-fold selectivity for p56lck over PKA and PKC and 40-fold selectivity over four receptor tyrosine kinases as well as 7–20-fold selectivity over the homologous enzymes p60src and p59fyn.
- p56lck tyrosine kinase inhibitor
Pale orange solid.
Soluble in DMSO.
Formula:
C₁₆H₁₀O₅ MW: 282.2 g/mol Storage Temperature: Freezer |
CAS Number:
477-84-9 |
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