RG-13022 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
3-(3,4-Dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile
, Tyrphostin RG 13022
RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.
- Tyrosine kinase inhibitor
White solid.
Soluble at 25mg/ml in DMSO or 100% ethanol.
Formula:
C₁₆H₁₄N₂O₂ MW: 266.3 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00236444 CAS Number: 136831-48-6 |
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