AG-494 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
Tyrphostin AG 494
, (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide
AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.
- EGFR inhibitor
Yellow solid.
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Formula:
C₁₆H₁₂N₂O₃ MW: 280.3 g/mol Storage Temperature: Ambient |
MDL Number:
MFCD00209863 CAS Number: 133550-35-3 |
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