LY2183240 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Anandamide transporter inhibitor
A potent inhibitor of anandamide uptake (IC50=7.3nM). Systemic administration to rodents elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain. LY2183240 also inhibits FAAH hydrolytic activity (IC50=12.4nM) as well as other brain serine proteases and represents a new chemotype for the design of new selective FAAH inhibitors. Radiolabeled LY2183240 has been used to identify a high-affinity, saturable anandamide transporter binding site on RBL-2H3 cell membranes distinct from FAAH.
CAS Number:
874902-19-9 |
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