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Mdivi -1 ≥97% (by HPLC)

Supplier: Enzo Life Sciences

Mdivi -1 ≥97% (by HPLC)

Mdivi -1 ≥97% (by HPLC)

Synonyms: 3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one , 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone

BML-CM127-0050 BML-CM127-0010

89156-982EA 510.79 USD

89156-982 89156-980

Mdivi -1 ≥97% (by HPLC)

Mdivi -1

Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (50= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1. It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC50 of 1-10µM but is not a general inhibitor of GTPases.

Inhibitor of mitochondrial division

White solid.

Soluble in DMSO (25mg/ml).

Formula: C₁₅H₁₀Cl₂N₂O₂S
MW: 353.2 g/mol
Storage Temperature: Freezer

MDL Number: MFCD00974506
CAS Number: 338967-87-6

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