Xestospongin C ≥90% (by TLC)
Supplier: Enzo Life Sciences
Synonyms:
Araguspongine E
, XeC
, (1R,4aR,11R,12aS,13S,16aS,23R,24aS)-Eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b']dipyridine
Xestonspongin C is a structurally novel marine alkaloid isolated from the Okinawan sponge Xestospongia sp. It is a potent, cell-permeable inhibitor of IP3 receptor-mediated Ca2+ release (IC50 = 358 nM). However, since xestospongin C also inhibits voltage-dependent Ca2+ and K+ currents at concentrations similar to those which inhibit the IP3 receptor, it can only be regarded as a selective blocker of the IP3 receptor in permeabilized cells and not in cells with intact plasma membranes. Has vasodilatory properties.
- IP3 receptor inhibitor
White to off-white powder.
Soluble in DMSO or 100% ethanol at 2mM.
Formula:
C₂₈H₅₀N₂O₂ MW: 446.71 g/mol Storage Temperature: Freezer |
MDL Number:
MFCD01862629 CAS Number: 88903-69-9 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...