Hypothemycin (from Phoma sp.) ≥97% (by HPLC)

380-116-C250 380-116-M001
89150-042EA 1605.26 USD
89150-042 89150-040
Hypothemycin (from Phoma sp.) ≥97% (by HPLC)
Hypothemycin

MEK inhibitor. Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes.


Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation


Hypothemycin inhibited the growth of HT29 and HCT116 cells in serum-free defined medium. IC50 at 0.078 mM and 0.90 mM, respectively. Hypothemycin concurrently inhibitis Kit- and FcepsilonRI-mediated signaling.


Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies.


White to off-white solid


Soluble in DMSO or acetone, Insoluble in methanol or water


Packaging: Shipping temperature: Ambient

Formula: C₁₉H₂₂O₈
Storage Temperature: Freezer
CAS Number: 76958-67-3

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