Hypothemycin (from Phoma sp.) ≥97% (by HPLC)
MEK inhibitor. Exhibits antifungal and cytotoxic activity against some tumor cell lines partly attributed to inhibition of Ras-inducible genes.
Inhibits proliferation of mouse and human T cells and modulates production of cytokines during T cell activation
Hypothemycin inhibited the growth of HT29 and HCT116 cells in serum-free defined medium. IC50 at 0.078 mM and 0.90 mM, respectively. Hypothemycin concurrently inhibitis Kit- and FcepsilonRI-mediated signaling.
Facilitates the ubiquitinylation process of cyclin D1. Has been identified as a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in both in vitro and in vivo studies.
White to off-white solid
Soluble in DMSO or acetone, Insoluble in methanol or water
Packaging: Shipping temperature: Ambient
Formula:
C₁₉H₂₂O₈ Storage Temperature: Freezer |
CAS Number:
76958-67-3 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...