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Tautomycin, Enzo Life Sciences

Supplier: Enzo Life Sciences
Inhibitor of PP1 and PP2A.

  • Isolated from Streptomyces spiroverticillatus

Cell permeable protein phosphatase inhibitor. Inhibits PP1 completely at 3nM and PP2 at 30nM. Inhibition of PP2B is over 10.000 fold weaker and PP2C is not inhibited. Structurally similar to okadaic acid but has opposite relative potency for PP1 and PP2A. Its cell permeability and unique inhibitory profile make tautomycin a useful tool for identifying phosphatase subtypes and physiological substrates for PP2 and PP2A.

Treatment of MCF7 cells (breast caner line) with 10µM produced time-dependent inhibition of PP1 (~80% in 6h, 100% in 14 h), with only 20% inhibition of PP2A after 24h.

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Size Supplier No. VWR Catalog Number Unit Price Quantity
25 µg 380-041-C025 89149-880 Each Retrieving Restricted
50 µg 380-041-C050 89149-882 Each Retrieving Restricted
100 µg 380-041-C100 89149-884 Each Retrieving Restricted
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Molecular weight 767.0
CAS No. 109946-35-2
Purity ≥85% (HPLC)
Solubility Soluble in 100% ethanol, methanol or DMSO
Appearance Colorless film
Shipping Temperature Ambient
Storage Conditions -20 °C
Chemical Formula C41H66O13
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