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Celastrol ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Celastrol ≥98% (by HPLC)

Celastrol ≥98% (by HPLC)

Synonyms: Tripterin

350-332-M025 350-332-M005

89149-518EA 116.82 USD

89149-518 89149-520

Celastrol ≥98% (by HPLC)

Celastrol

Anti-inflammatory and immunosuppressive

Cell permeable triterpenoid; anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerase II.

Isolated from the root of Tripterygium sp.

Formula: C₂₉H₃₈O₄
MW: 450.62 g/mol

MDL Number: MFCD03424073
CAS Number: 34157-83-0

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